Per a prost from AMD via Reddit, we can expect an AGESA update shortly to address the known USB connectivity issues. AGESA 188.8.131.52 will be used to deploy this update to the masses:
We would like to thank the community here on r/AMD for its assistance with logs and reports as we investigated the intermittent USB connectivity you highlighted. With your help, we believe we have isolated the root cause and developed a solution that addresses a range of reported symptoms, including (but not limited to): USB port dropout, USB 2.0 audio crackling (e.g. DAC/AMP combos), and USB/PCIe Gen 4 exclusion.
AMD has prepared AGESA 184.108.40.206 to deploy this update, and we plan to distribute 220.127.116.11 to our motherboard partners for integration in about a week. Customers can expect downloadable BIOSes containing AGESA 18.104.22.168 to begin with beta updates in early April. The exact update schedule for your system will depend on the test and implementation schedule for your vendor and specific motherboard model. If you continue to experience intermittent USB connectivity issues after updating your system to AGESA 22.214.171.124, we encourage you to download the standalone AMD Bug Report Tool and open a ticket with AMD Customer Support.